A comparison of invasive lobular carcinoma with other invasive breast cancers at Tygerberg Academic Hospital

Keywords: breast cancer, invasive lobular carcinoma, combined hormonal replacement therapy

Abstract

Background: The second most common histological subtype of invasive breast carcinoma is invasive lobular carcinoma (ILC) occuring with a frequency 10–15% in Western countries and approximately 5%, in Africa, the Middle East and Asia (AMA). Combined hormone replacement therapy (CHRT) is a risk factor for the development of ILC which is infrequently diagnosed at our centre. This study aimed to investigate the incidence and clinicopathological characteristics of ILC as compared to invasive breast carcinoma of no special type (IBC-NST).

Methods: Clinical and pathological data on breast carcinoma patients attending the breast and endocrine unit at Tygerberg Academic Hospital since 2017 have been recorded on a Stellenbosch University REDCap® database.

Results: IBC-NST was the most frequent subtype diagnosed (83.9%) and ILC the second most common subtype (5.2%). Most ILCs were of luminal B intrinsic subtype, and the median size was slightly smaller than IBC-NST. There were significantly more grade 2 ILCs than IBC-NSTs (81.5% vs 50.9%). There was no statistical difference between stage and histological subtype.

Conclusion: ILC has clinicopathological differences when compared to IBC-NST, although these were less pronounced in this study. The prevalence of ILC was similar to numbers reported in AMA. We hypothesise that there may be a discrepancy in the prevalence of ILC between public and private healthcare systems in South Africa, and that it may be due to differing trends in prescribing CHRT.

Author Biographies

L J De Jager, Stellenbosch University

Division of Anatomical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and National Health Laboratory Service, Tygerberg Academic Hospital, South Africa

P T Schubert, Stellenbosch University

Division of Anatomical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and National Health Laboratory Service, Tygerberg Academic Hospital, South Africa

K Baatjes, Stellenbosch University

Breast and Endocrine Unit, Division of Surgery, Department of Surgical Sciences, Tygerberg Academic Hospital, Stellenbosch University, South Africa

W Conradie, Stellenbosch University

Breast and Endocrine Unit, Division of Surgery, Department of Surgical Sciences, Tygerberg Academic Hospital, Stellenbosch University, South Africa

J Edge, Stellenbosch University

Breast and Endocrine Unit, Division of Surgery, Department of Surgical Sciences, Tygerberg Academic Hospital, Stellenbosch University, South Africa

Published
2022-09-21
How to Cite
De Jager, L., Schubert, P., Baatjes, K., Conradie, W., & Edge, J. (2022). A comparison of invasive lobular carcinoma with other invasive breast cancers at Tygerberg Academic Hospital. South African Journal of Surgery, 60(3), 176-181. Retrieved from http://sajs.redbricklibrary.co.za/index.php/sajs/article/view/3768
Section
Breast