The role of Ki-67 in breast cancer

  • Aylwyn Mannell University of the Witwatersrand

Abstract

The proliferative marker, Ki-67, is a human nuclear antigen, and forms an integral part of cell division in both normal and malignant tissue. Since the hallmark of cancer is uncontrolled and relentless cell proliferation, the Ki-67 proliferative index is increasingly used to assess and manage breast cancer. The value of Ki-67 as a prognostic indicator, a guide to the selection of therapy, and a method of measuring response to ongoing treatment, is examined in this review.

Author Biography

Aylwyn Mannell, University of the Witwatersrand

FRACS, FRCS(Lond) MS(Syd)
Associate Professor
Department of Surgery
University of the Witwatersrand

Published
2016-06-29
How to Cite
Mannell, A. (2016). The role of Ki-67 in breast cancer. South African Journal of Surgery, 54(2), 10-13. Retrieved from http://sajs.redbricklibrary.co.za/index.php/sajs/article/view/1911
Section
Review